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Exfoliated malignant cells from cervical smears of 34 cases of ca. in situ were investigated for sex chromatin incidence and various chromatin patterns. The following results were obtained. 1. The finely granulated chromatin patterns were observed in 54.1% of 2,481 cells. 2. The average incidence of sex chromatin positive unclei was 7.8%(0-19.5%). 3. In the malignant cell count on the area 18x18mm², there were 5 cases of less than 50 cells, 14 cases between 50 and 100 cells, 6 cases between 101 and 150 cells, 2 cases between 151 and 200 cells and 7 cases more than 201 cases, respectively. The smallest and the largest number of cells were 25 cells and 413 cells, respectively. 4. The cases of each predominant subgroup were 4 cases in subgroup 1, 4 cases in subgroup 2 and 21 cases in subgroup 3. The other 5 cases whowed a mixture of chromatin patterns without predominance of one of the subgroup. 5. The frequency of sex chromatin positive nuclei in the finely granulated cells were 21 cases below the 10% and 13 cases between 10.1 and 20%. The frequency of double sex chromatin positive nuclei in the finely granulated cells was 2 cases. 6. The incidence of sex chromatin positive nuclei in the 45 cases of normal vaginal epithelium and 34 cases of cervical ca. in situ were 23.1±1.16% and 7.8%±1.32%, respectively. The difference was noted between the two groups(P<0.01).
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